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Hrln (hrar alpha) cell line

HRLN were generated by transfection of cervical cancer HeLa cells with the (RARE)3-TK-Luciferase-SV40-Neomycin plasmid. rnThe plasmid (RARE)3-TK-Luc-SVNeo contains a luciferase gene driven by three retinoid receptor responsive element (RARE) in front of thymidine kinase promoter and a neomycin phosphotransferase gene under the control of SV40 promoter. rn
Interest / Relevance: These cells enable to measure the hRAR alpha activity (full and partial agonism, antagonism) of pharmaceuticals (breast cancer, menopause treatment), environmental compounds (alkylphenols, bisphenol A, phthalates or pesticides, cosmetics). rnThese cells enable to measure the hRAR alpha activity of environmental (water, sediments), human (blood, urine adipose tissue) or food (water, vegetables, meat) samples.rnrnTTNPB EC50 0.8 nMrn
Keywords: hRAR alpha, luciferase, natural, pharmaceutical and environmental retinoids
Scientist's name: Patrick BALAGUER
Patrick Balaguer
Publications:
Balaguer P Boussioux AM Demirpence E Nicolas JC. Reporter cell lines are useful tools for monitoring biological activity of nuclear receptor ligands. Luminescence. 2001 16:1 53-8.

Reference:

RT00623

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Inserm Transfert
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Rare disease: No
Last update: 08/07/2024

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