Anti-kiaa0753 rat monoclonal antibody 17d4

This antibody recognizes the human KIAA0753 protein (also named OFIP or MNR). The epitope is located at the carboxy terminus of the protein, between residues 885 and 967. It detects endogenous KIAA0753 in various cell lines using immunoblot and immunofluorescence techniques.

Interest / Relevance: KIAA0753 is a centrosome and centriolar satellite protein involved in primary cilia formation and centriole duplication. The KIAA0753 gene is mutated in somes patients with Joubert and OFD syndroms, two ciliopathies of genetic origin. This antibody is of interest both in a basic research and clinical context.
Keywords: Cilia , Centrosome , Ciliopathy , Microtubule
Scientist's name: Olivier ROSNET
Véronique Chevrier, Daniel Birnbaum

Reference:

RT00504

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Olivier ROSNET
Inserm Transfert
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Clones available: 17D4
Isotype: lgG2a
Source: Rat
Specificity: Human
Cellular Distribution: Centrosome, centrioles, centriolar satellites
Last update: 05/12/2019

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