Animal models of fibrosis

UUO: This model is induced in mice or rats by unilateral ureteral ligation (UUO) of the left ureter. The animals rapidly develop, within a few days, severe tubulo-interstitial renal fibrosis with an inflammatory cell infiltrate in the affected kidney.

SNX: This model consists at reducing the renal mass by 83%. This induces hyperfiltration and induces over a period of around 6 months significant fibrotic lesions in C57bl/6j mice and in 2 months in Swiss mice. In rats the model is somewhat faster as it induces renal fibrosis in 3 months.

Interest / Relevance: UUO: This is an ideal go or no-go model to test the potential anti-fibrotic activity of (new) compounds.

SNX: This is a more chronic model of the development of fibrosis somewhat closer to what is observed in humans than the UUO model.

Keywords: Chronic kidney disease , Fibrosis , In vivo drug evaluation

Scientist's name: Joost SCHANSTRA
Jean-Loup BASCANDS

Publications:

UUO: Schanstra, J. P., Neau, E., Drogoz, P., Arevalo Gomez, M. A., et al., In vivo bradykinin B2 receptor activation reduces renal fibrosis. J Clin Invest 2002.

UUO: Pradere, J. P., Klein, J., Gres, S., Guigne, C., et al., LPA1 receptor activation promotes renal interstitial fibrosis. J Am Soc Nephrol 2007

SNX: Schanstra, J. P., Bachvarova, M., Neau, E., Bascands, J. L. and Bachvarov, D., Gene expression profiling in the remnant kidney model of wild type and kinin B1 and B2 receptor knockout mice. Kidney Int 2007

Reference:

RT00449