147

therapeutic
published patents

56

oncology
published patents

310

research tools

46

diagnostic
published patents

Our Technology Offers

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You want access to an innovative offer which is based on the excellence of Inserm, the leading academic research and clinical institute dedicated to human health in Europe? Find out our technologies offers of patents and research tools: here is a sample of our patents.

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Transgenic mouse model for myotonic dystrophy: dmsxl carrying

This transgenic mice model contains large human genomic DNA sequence carrying the DMPK gene with very large repeat (>1200 CTG). They show […]

Microbiota dependent spontaneous colorectal cancer

100% of the animals spontaneously tumor in the distal part of the colon after 7 month of age, or within 5 weeks after bone marrow transfer. The […]

Gfp-tagged mucin-reporter mouse model

To follow the Muc5b gel-forming mucin production, we tagged with a GFP variant the corresponding gene. This reporter mouse allows to follow goblet […]

Prkcdg510s/g510s mice – preclinical model of lupus

We introduced the Prkcd G510S mutation that we previously associated to a Mendelian cause of SLE in the mouse genome, by means of CRISPR-Cas9 gene […]

Transgenic mouse model for myotonic dystrophy: dm300 carrying 300 ctg

Transgenic mouse model carrying the myotonic dystrophy type 1 (DM1) locus (45kb of human sequences) with the DMPK gene and about 300 unstable CTG […]

Tp53inp1-deficient mouse

This mouse is deficient for TP53INP1 (both isoforms TP53INP1alpha and TP53INP1beta). TP53INP1 is a key stress factor endowed with a tumor suppressor […]

Mouse models of amyloidosis

Amyloidosis is a rare disease caused by extracellular deposition of insoluble abnormal fibrils derived from aggregation of a misfolded variant of a […]

Lgi1-null mouse: a model for epilepsy

LGI1 (leucine-rich, glioma-inactivated 1) mutations are responsible for an inherited focal epileptic syndrome with onset in adolescence. LGI1-related […]

Dba/1-abca1tm1jdm/j mice

The mutant ABC1 allele was generated by homologous recombination, by using a targeting vector containing a neomycin resistance and herpes simplex […]

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