Scavenger receptor bi knockout mouse

The class B, type I scavenger receptor (Srb1 or Scarb1) is a cell surface HDL receptor. It plays a key role in determining the levels of plasma lipoprotein cholesterol (primarily HDL) and the accumulation of cholesterol stores in the adrenal gland. Homozygous females are infertile if the diet is not supplemented with probucol; homozygous males are fertile. A cross between heterozygotes will generate homozygous pups at a normal mendelian ratio if the breeding pair are fed with a probucol supplemented diet.

Interest / Relevance: *HDL metabolism and atherosclerosis studies: SRBI KO mice have an impaired Reverse Cholesterol transport and develop large atherosclerotic lipid lesions (See Ref 1)
*Coronary heart disease: Double KO mice for the SR-BI and apoE genes may be a useful tool in studies related to coronary heart disease (See Ref 2)
*Plasmodium Infection: Scavenger Receptor BI Boosts Hepatocyte
Permissiveness to Plasmodium Infection (See Ref 3)

Keywords: SR-BI , atherosclerosis , HDL-cholesterol , Plasmodium

Publications:

1 - Huby T, Doucet C, Dachet C, Ouzilleau B, Ueda Y, Afzal V, Rubin E, Chapman MJ, Lesnik P 2006 Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues. J Clin Invest 116:2767-76

2 - Braun A; Trigatti BL; Post MJ; Sato K; Simons M; Edelberg JM; Rosenberg RD; Schrenzel M; Krieger M. 2002. Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Circ Res 90(3):270-6.

3 - Yalaoui S, Huby T, Franetich JF, Gego A, Rametti A, Moreau M, Collet X, Siau A, van Gemert GJ, Sauerwein RW, Luty AJ, Vaillant JC, Hannoun L, Chapman J, Mazier D, Froissard P 2008 Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection. Cell Host Microbe 4:283-92

Reference:

RT00307