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Tailor made high-fat diet fed diabetic mice

We can provide mice a nutritional model of mice which become either type 2 diabetic without obesity, or obese and diabetic or mainly obese.

Interest / Relevance: The interest is related to the targeted disease: diabetes or obesity or metabolic syndrome. it is noteworthy that the diabetic animal can be obtained within a month.
these mice are very well adapted for the study of GLP-1 based and antiinflammatory therapies

Keywords: incretins , high fat diet , diabetes , obesity , nutritionnal

Publications:

1. Burcelin R, Crivelli V, Dacosta A, Roy-Tirelli A, Thorens B: Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet. Am J Physiol Endocrinol Metab 282:E834-842, 2002
2.Sulpice T, Prunet-Marcassus B, Molveaux C, Cani PD, Vitte PA, Graber P, Dreano M, Burcelin R: An adiponectin-like molecule with antidiabetic properties. Endocrinology 150:4493-4501, 2009
3.Riant E, Waget A, Cogo H, Arnal JF, Burcelin R, Gourdy P: Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice. Endocrinology 150:2109-2117, 2009

Reference:

RT00404

Type of research tool: Laboratory Animals

Therapy area(1): Metabolic Disorders

Therapy area(2): Nutritional disorder

Therapy area(3): Immunology

Therapy area(4): Gastrointestinal Diseases

Uses(1): Academic Research

Uses(2): Proof of concept in vivo

Uses(3): Industry Research (screening, tox.studies, bioreactor, ...)

Uses(4): Diagnostic

Uses(5): Therapeutic

Antibody applications: In vivo studies

Inserm Transfert
Research Tools

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Species: Mouse

Genotype: Wild type

Strain: C57bl6

Genetic Background: C57bl6

Applications: Type 2 diabetes, obesity, metabolic syndrome

Rare disease: No

Last update: 11/09/2024

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