147

therapeutic
published patents

56

oncology
published patents

310

research tools

46

diagnostic
published patents

Our Technology Offers

Welcome to our Technology Offers website

You want access to an innovative offer which is based on the excellence of Inserm, the leading academic research and clinical institute dedicated to human health in Europe? Find out our technologies offers of patents and research tools: here is a sample of our patents.

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Cellular fibronectin toolset

Expression vectors encoding human cellular fibronectin variants harboring the alternatively spliced Extra Domains B and/or A (or neither) ; […]

Selective antiestrogen binding site (aebs) ligands in the diphenyl

We can offer and produce selective AEBS lignads for research purpose only.rnThese compounds are potent inducers of breast cancer cell differentiation […]

Establishment of redifferentiated cells after treatment of neoplastic

When undifferentiated, invasive neoplastic cell lines are treated with an optimal time / concentration combination of curcumin (under conditions […]

Staining of human tissues for multi-color confocal microscopy analysis

This proposition describes a technique that allowed us to successfully stain human tissues with fluorochrome labelled antibodies for confocal and […]

Ex vivo culture system for screening compounds targeting

A novel, ex vivo niche-based hypoxic culture system for maintaining Leukaemia Initiating Cells (LICs) from patients and an associated method to […]

Highly differentiated human hepatocytes in primary culture

Hepatocytes are isolated from human liver and cultured in a system that allows to maintain a highly differentiated phenotype for several weeks.rnIn […]

Profiling blood lymphocytes reactivity against cancer cells

In vitro trogocytosis of PKH67-stained cancer cells as a measure of their interactions with bulks of PBMC from patients. This profiling give the […]

Three-dimensional multicellular spheroid cultures

When culture in suspension many mammalian cell types can aggregate into 3D-spheroids. These multicellular cultures mimic real tissues or tumours and […]

Screening and characterization of new histone deacetylase inhibitors

Using BRET technology, we designed a method to measure histone acetylation in living cells. Cells are transfected with a vector coding for a […]

Xenograft models to study stem and chemoresistant cells, and to assess

We have recently contributed to establish a robust xenotransplantation model (NSG, NRG) to study the leukemic engraftment as well as the stem cell […]

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