Rat transformed mesothelial cell line F5-3

Transformed rat mesothelial cell line (= myofibroblast) isolated from the peritoneal fibrosis observed in a female rat (Fischer F344) after 415 days of induction with crocidolite (blue asbestos) injected intraperitoneously in 2008.
Belongs to the sarcomatoid group (see publication 1) later classified in "PNsarc2" subgroup according to high Hif1a, Ccl7, and Vegfa levels (see publication 2 below for more details).
The complete proteomic analysis data of the biocollection of cell lines has been deposited on the PRIDE database website (http://www.ebi.ac.uk/pride), part of the ProteomeXchange Consortium, with the dataset identifier PXD060521.

Interest / Relevance: - Academic research: investigation of Epithelial Mesenchymal transition (EMT), studies of metastatic potential in malignancy, renal fibrosis...

- Industry research: antibody production, screening of new anticancer agents, identification of factors that increase mesothelial proliferation and migration.

- Therapeutic research: development of cancer vaccines, regenerative medicine applications.

Keywords: mesothelial cells, sarcomatoid, EMT, Tumor marker, Tumor invasion process, Malignant transformation, Proliferation rate

Scientist's name: M Daniel L. POULIQUEN

Publications:

1- Oncotarget (2016) 7, 34664-34687, doi: 10.18632/oncotarget.8970

2- Cancers (2020) 12, 939, doi: 10.3390/cancers12040939

Reference:

RT00458