Rat mesothelioma cell line F4-T2

Neoplastic rat cell line isolated from tumor masses (peritoneal mesothelioma) collected in the peritoneal cavity of a male rat (F344) after 387 days of induction with crocidolite (blue asbestos) injected intraperitoneously in 2008.
Classified as mildly invasive (see publications / illustrations below).
The complete proteomic analysis data of the biocollection of cell lines has been deposited on the PRIDE database website (http://www.ebi.ac.uk/pride), part of the ProteomeXchange Consortium, with the dataset identifier PXD060521.

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Interest / Relevance: - Academic Research: identification of markers of neoplastic / transformed mesothelial cells, analyses of chromosomal damage induced by asbestos, studies of the mechanism of asbestos-induced oncogenesis.

- Industry research: antibody production, screening of new anticancer agents, identification of factors implicated in mesothelioma cell proliferation, migration, and invasion.

- Therapeutic: development of epigenetic drugs, design of cancer vaccines.

Keywords: mesothelial cells, tumor marker, tumor invasion process, malignant transformation, proliferation rate

Scientist's name: M Daniel L. POULIQUEN

Publications:

1- Oncotarget (2016) 7, 34664-34687, doi: 10.18632/oncotarget.8970

2- Cancers (2020) 12, 939, doi: 10.3390/cancers12040939

3- Oncotarget (2018) 9, 16311-16329, doi: 10.18632/oncotarget.24632

4- Cancers (2020) 12, 2430, doi: 10.3390/cancers12092430

5- Cancers (2023) 15, 3044, doi: 10.3390/cancers15113044

Reference:

RT00419