Rat anti-mouse cd8 beta subunit (mouse cd8beta) (clone h37-17.2)

Thymus-derived CD8+ TCRab+ T cells typically express heterodimeric CD8ab consisting of a disulfide-linked a and b chain. CD8 can also be expressed as homodimeric CD8aa, namely on intra-epithelial T lymphocytes, some dendritic cells, NK, NKT and TCRcd+ T cells. Both forms of CD8 bind to the non-polymorphic domain of MHC class Ia molecules and associate via CD8a with the intracellular Src tyrosine kinase p56lck

Interest / Relevance: Reagents allowing to study the expression, membrane distribition and functions of CD8 ab heterodimers.
Keywords: CD8beta
Scientist's name: Michel PIERRES
Philippe NAQUET (CIML)

Reference:

RT00347

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Michel PIERRES
Inserm Transfert
Research Tools
Clones available: H37-17.2
Isotype: lgG2b
Source: Rat
Specificity: Mouse
Immunogen Seq ID: Alloactivated BALB/c cytotoxic T cells.
Cellular Distribution: Thymus-derived CD8+ TCRab+ T cells
Depositor: Michel PIERRES
FBS: 10%
Rare disease:
Last update: 14/01/2022

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