Rat anti-mouse cd11a/cd18 (mouse lfa-1 alpha/beta conformational determinants) (several clones)

Two rat monoclonal anti-mouse LFA-1 recognizing two spatially distinct conformational determinants, the expression of which requires the CD11a/CD18 subunits pairing.
Epitope B : H154-266 (IgG2a) ; Epitope E : H155-78 (IgG1)

Interest / Relevance: In contrast to the MAb specific of the CD11a, these two rat monoclonal antibody do not inhibit mouse T cell responses. Furthermore, the LFA-1-E monoclonal antibody (H155-78) potentiates the latter (T cell proliferation and Il-2 production). H155-78 is widely used as an early marker of mouse immune synapse formation during which the LFA-1 molecule is rapidly redistributed and upregulated.

Keywords: mouse LFA-1 , CD11a/CD18 , Activating anti-LFA-1 monoclonal , Marker of immune synapse

Scientist's name: Philippe NAQUET
Michel PIERRES

Publications:

Pont, S. et al. Identification of 5 topographic domains of the mouse LFA-1 molecule : subunit assignment and functional involvement in lymphoid cell interactions. (1986) J. Immunol. 136 :3750-3759

Mary A. Markiewicz* at al. Costimulation through NKG2D Enhances Murine CD8+ CTL Function: Similarities and Differences between NKG2D and CD28 Costimulation.The Journal of Immunology, 2005, 175: 2825-2833.

Reference:

RT00356

Type of research tool: Antibodies

Therapy area(1): Immunology

Uses(1): Academic Research

Uses(2): Proof of concept in vitro

Uses(3): Industry Research (screening, tox.studies, bioreactor, ...)

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Clones available: Epitope B : H154-266 (IgG2a)
Epitope E : H155-78 (IgG1)

IgG2a & IgG1

Isotype: IgG2a & IgG1

Source: Rat

Specificity: Mouse

Immunogen Seq ID: Activated mouse T cells

Depositor: Michel PIERRES

FBS: 10%

Rare disease: No

Last update: 11/09/2024

Rat anti-mouse cd11a/cd18 (mouse lfa-1 alpha/beta conformational determinants) (several clones)

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