BIO15247-T1

Nanoblade technology: High efficiency delivery of CRISPRs components in primary cells by Virus Like Particles.

The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.


Keywords : CRISPR, Cas9, Virology, Gene editing, Gene therapy
Patent Application number : EP 15 306678.2 : METHODS AND PRODUCTS FOR GENETIC ENGINEERING
PCT/EP2016/075289
Patent Application date : 2015-10-20
Multidisciplinary field : -
Technology/Engineering : Gene editing
Technological Platform : -
Rare disease : -
Second indication : -
Inventors : -
Publications :
  • Efficient genome editing in primary cells and in vivo using viral-derived "Nanoblades" loaded with Cas9/sgRNA ribonucleoproteins https://www.biorxiv.org/content/early/2017/10/12/202010

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