Nanoblade technology: high efficiency delivery of crisprs components in primary cells by virus like particles.

The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.

Keywords: CRISPR, Cas9, Virology, Gene editing, Gene therapy
Patent Application number: EP 15 306678.2 : METHODS AND PRODUCTS FOR GENETIC ENGINEERING
PCT/EP2016/075289
Publications:
Efficient genome editing in primary cells and in vivo using viral-derived "Nanoblades" loaded with Cas9/sgRNA ribonucleoproteins https://www.biorxiv.org/content/early/2017/10/12/202010

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