Mouse anti-human/mouse/rat tspan5 (clones ts5-2 and ts5-3)

This mAb recognizes Tspan5, a member of the Tetraspanin superfamily. It recognizes the human, mouse and rat proteins which are 100% identical. First Tspan5 mAb ever produced.

Interest / Relevance: Tspan5 is a new regulator of Notch signaling through an action on the protease ADAM10.

Keywords: Tetraspanin, ADAM10, Notch

Scientist's name: Eric RUBINSTEIN
Martine BILLARD,Stephanie CHARRIN

Publications:

Eschenbrenner E Jouannet S Clay D Chaker J Boucheix C Brou C Tomlinson MG Charrin S Rubinstein E. TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life. Life Sci Alliance. 2019 Dec 23(1):e201900444. doi: 10.26508/lsa.201900444. PMID: 31792032.Saint-Pol J Eschenbrenner E Dornier E Boucheix C Charrin S Rubinstein E. Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins. Biochem Soc Trans. 2017 Aug 1545(4):937-944. doi: 10.1042/BST20160296.

Reference:

RT00510

Type of research tool: Antibodies

Therapy area(1): Central Nervous System

Therapy area(2): Oncology

Therapy area(3): Others

Uses(1): Academic Research

Inserm Transfert
Research Tools

E-mail

Clones available: TS5-2, TS5-3

Isotype: lgG2a

Source: Mouse

human, mouse, rat

Specificity: human, mouse, rat

Immunogen Seq ID: Tspan5 KO mice (C57/B6) were immunized with U2OS cells transfected with Tspan5-GFP, Final boost with a Tspan5 immunoprecipitate

Cellular Distribution: large, higher expression in the brain and the ovary

Rare disease: No

Last update: 08/07/2024

Mouse anti-human/mouse/rat tspan5 (clones ts5-2 and ts5-3)

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