Mouse anti-human/mouseat tspan5 (clones ts5-2 and ts5-3)

This mAb recognizes Tspan5, a member of the Tetraspanin superfamily. It recognizes the human, mouse and rat proteins which are 100% identical. First Tspan5 mAb ever produced.

Interest / Relevance: Tspan5 is a new regulator of Notch signaling through an action on the protease ADAM10.

Keywords: Tetraspanin, ADAM10, Notch

Scientist's name: Eric RUBINSTEIN
Martine BILLARD,Stephanie CHARRIN

Publications:

Eschenbrenner E, Jouannet S, Clay D, Chaker J, Boucheix C, Brou C, Tomlinson MG, Charrin S, Rubinstein E. TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life. Life Sci Alliance. 2019 Dec 2,3(1):e201900444. doi: 10.26508/lsa.201900444. PMID: 31792032.
Saint-Pol J, Eschenbrenner E, Dornier E, Boucheix C, Charrin S, Rubinstein E. Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins. Biochem Soc Trans. 2017 Aug 15,45(4):937-944. doi: 10.1042/BST20160296.

Reference:

RT00510

Type of research tool: Antibodies

Therapy area(1): Central Nervous System

Therapy area(2): Oncology

Therapy area(3): Others

Uses(1): Academic Research

Inserm Transfert
Research Tools

E-mail

Clones available: TS5-2, TS5-3

Isotype: lgG2a

Source: Mouse

human, mouse, rat

Specificity: human, mouse, rat

Immunogen Seq ID: Tspan5 KO mice (C57/B6) were immunized with U2OS cells transfected with Tspan5-GFP, Final boost with a Tspan5 immunoprecipitate

Cellular Distribution: large, higher expression in the brain and the ovary

Rare disease: No

Last update: 11/09/2024

Mouse anti-human/mouseat tspan5 (clones ts5-2 and ts5-3)

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