Mouse anti-human melanoma associated antigen (clone kba.62)

- Anti-melanoma associated antigen reactive on paraffin sections.
- KBA.62 is useful in ascertaining the immunomorphological diagnosis of malignant melanoma in routinely processed paraffin sections.
- Staining is localised predominantly to the cell membrane with little or no cytoplasmic reactivity. Negative staining is observed in the majority of human non-melanocytic neoplasms.

Interest / Relevance: - Immunohistochemical diagnosis of primary and mmelanome.
- Detection of melanoma cells in the sentinel lymph node.
- KBA.62 reacts strongly and uniformly with the majority of benign and malignant melanocytic proliferations. KBA.62 antibody is a useful additional marker for melanoma, specifically in desmoplastic/spindle cell cases.
Scientist's name: Georges DELSOL
Mohamad Talal AL SAATI
Publications:
- Production and characterisation of an antimelanoma monoclonal antibody KBA.62 using a new melanoma cell line reactive on paraffin wax embedded sections. Cohen-Knafo E, al Saati T, Aziza J, Ralfkiaer E, Selves J, Gorguet B, Delsol G. J Clin Pathol. 1995 Sep;48(9):826-31.

- KBA.62: a useful marker for primary and metastatic melanomasPagès C, Rochaix P, al Saati T, Valmary-Degano S, Boulinguez S, Launay F, Carle P, Lauwers F, Payoux P, Le Guellec S, Brousset P, Lamant L.
Hum Pathol. 2008 Aug;39(8):1136-42. Epub 2008 May 20

Reference:

RT00385

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Clones available: KBA.62
Isotype: lgG2a
Source: Mouse
Specificity: Human
Immunogen Seq ID: KAL human melanoma cell line
Know Cross Reactivity: endothelial cells
FBS: 15%
Rare disease: No
Last update: 11/09/2024

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