Microbiota dependent spontaneous colorectal cancer

100% of the animals spontaneously tumor in the distal part of the colon after 7 month of age, or within 5 weeks after bone marrow transfer. The mutation affect the immune system and not the stromal cells. Tumor development is totally prevented in the absence of microbiota.

Interest / Relevance: Analysis of cancer treatment.
Analysis of microbiota effects on cancer.
Analysis of metabolism effetcs on cancer.
Keywords: microbiota , Colorectal cancer

Reference:

RT00491

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Julien MARIE
Inserm Transfert
Research Tools
Species: Mus musculus
Genotype: Mutation within the immune system
Genetic Background: C57BL/6
Last update: 27/05/2020

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