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Heln cell line

HELN were generated by transfection of cervical cancer HeLa cells with the ERE-betaGlobin-Luciferase-SV40-Neomycin plasmid.

The plasmid ERE-betaGlob-Luc-SVNeo contains a luciferase gene driven by estrogen receptor responsive element (ERE) in front of beta-globin promoter and a neomycin phosphotransferase gene under the control of SV40 promoter.
Interest / Relevance: These cells are a negative control cell line for measurement of estrogenic activity.
Keywords: Estrogen receptors, luciferase, pharmaceutical and environmental estrogens
Scientist's name: Patrick BALAGUER
Patrick Balaguer
Publications:
Escande A Pillon A Servant N Cravedi JP Larrea F Muhn P Nicolas JC Cavailles V Balaguer P. Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta. Biochem Pharmacol. 2006 71: 1459-69.
Delfosse V Grimaldi M Pons JL Boulahtouf A le Maire A Cavailles V Labesse G Bourguet W Balaguer P. Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes. Proc Natl Acad Sci U S A. 2012 109 : 14930-5.
Delfosse V Grimaldi M Cavaillès V Balaguer P Bourguet W. Structural and Functional Profiling of Estrogen Receptors Environmental Ligands. Environ Health Perspect. 2014 122: 1306-13.

Reference:

RT00619

Business Developper
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Inserm Transfert
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Rare disease: No
Last update: 11/09/2024

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