Methods and compositions for treating liver disesases

The present invention relates to a method for treating a subject suffering from a liver disease comprising a step of administering said subject with a […]

Use of cd9 as a biomarker and as a biotarget in glomerulonephritis

The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) […]

Gaba administration induces alpha cell-mediated beta-like cell

GABA is an inducer of ?-to-?-like cell conversion in vivo. This conversion induces ? cell replacement mechanisms through the mobilization of […]

Trpv2 as a new therapeutic target to modulate blood brain barrier

The present invention relates to a method for modulating blood-brain barrier (BBB) in a subject comprising a step of administering said subject with a […]

Inhibition of nicotinamide phosphoribosyltransferase (nampt) for the

The present invention relates to a method for treating a subject suffering from melanoma resistant by administering to said subject an inhibitor of […]

Methods and pharmaceutical compositions for cardiac regeneration

The adult mammalian heart regeneration is largely prevented by the limited proliferative capacity of the resident cardiomyocytes (CMs). Here, the […]

Trek1/trek2 as targets for the treatment of migraine

Inventors have found that the MT mutation puts an alternative start codon in frame which leads to the translation of a second TRESK fragment. […]

Methods and pharmaceutical compositions for the treatment of

The present invention relates to methods and pharmaceutical compositions for the treatment of age-related cardiometabolic diseases. In particular, the […]

Inhibition of usp14 impairs melanoma cell survival and overcomes

The present invention relates to a method and composition for treating melanoma. More particularly, inventors have shown that high expression of USP14 […]

Slitrk6 as a target for cancers associated with activation of the mapk

The response of subjects suffering from cancer to MAPK inhibitors is dramatically impaired by secondary resistances and rapid relapse. So far, the […]