Gaba administration induces alpha cell-mediated beta-like cell neogenesis

GABA is an inducer of α-to-β-like cell conversion in vivo. This conversion induces α cell replacement mechanisms through the mobilization of duct-lining precursor cells that adopt an α cell identity prior to being converted into β-like cells, solely upon sustained GABA exposure. Importantly, these neo-generated β-like cells are functional and can repeatedly reverse chemically induced diabetes in vivo. Similarly, the treatment of transplanted human islets with GABA results in a loss of α cells and a concomitant increase in β-like cell counts, suggestive of α-to-β-like cell conversion processes also in humans. (Cell. 2017 Jan 12;168(1-2):73-85.e11)

Keywords: Arx, GABA, Pax4, endocrine pancreas, β cell regeneration
Patent Application number: EP12306172.3
Inventors:
Keith AL-HASANIMonica COURTNEYAhmed MANSOURINouha BEN-OTHMANElisabet GJERNESPatrick COLLOMBAT
Publications:
Cell. 2017 Jan 12;168(1-2):73-85.e11. doi: 10.1016/j.cell.2016.11.002. Epub 2016 Dec 1.

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