Anti-neurotensin mab for the treatment of cancer

The present invention relates to a neutralising antibody which is capable of binding to neurotensin with high affinity. The antibody of the present […]

Human monoclonal antibodies against orexin receptor type 1

The present invention relates to human monoclonal antibodies against orexin receptor type 1 (OX1R) and uses thereof for the treatment of cancer. […]

Il15 antagonist to treat inflammation

The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory […]

Gaba administration induces alpha cell-mediated beta-like cell

GABA is an inducer of ?-to-?-like cell conversion in vivo. This conversion induces ? cell replacement mechanisms through the mobilization of […]

Rock inhibitors to treat diabetic retinopathy

In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. […]

Gene therapy coding for anti-tau nanobody to treat rare tauopathies

The invention relates to generation, optimization and characterisation of VHH targeted against Tau MTBD (microtubule-binding domain) with high […]

Method to restore or improve cognitive functions

The present invention relates to the field of memory and cognitive functions. Here the inventors show that memory stimulations induce autophagy in the […]

New molecules for neurodegenerative pathologies : indirect ?-secretase

The present invention is directed to novel compounds and pharmaceutically acceptable salts or solvates thereof, and their use. […]

Enhancement of 5-fluorouracil cytotoxicity by pyridoxal 5’-phosphate

The invention relates to methods and pharmaceutical compositions for treating cancer in a subject in need thereof. The inventors thought that low […]

Methods of treating heart failure

Worldwide, 1% to 2% of the general adult population have heart failure (HF), which is accompanied by reduced quality of life, high morbidity, […]