Methods for improving relaxation of striated myocytes

The Inventors developed conditions allowing to efficiently detect differences in cardiomyocytes relaxation phases associated with increased […]

Methods and pharmaceutical compositions for inducing immune tolerance

The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. […]

Methods and compositions for treating skin afflictions

The present invention relates to a method for treating skin afflictions in a subject comprising a step of administering said subject with a […]

Anti- protease nexin-1 conformational single domain antibodies and

The present invention relates to anti-protease nexin-1 (PN-1) conformational single domain antibodies and uses thereof in particular in the […]

Correction of beta-thalassemia phenotype by genetically engineered

The present invention relates to a genetically modified hematopoietic stem cell(HSC) comprising, in at least one ?-globin gene comprised in the genome […]

Antibodies specific for il20-rb and uses thereof for the treatment of

Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality worldwide. Acute exacerbation of COPD (AE-COPD) in […]

Selective pharmacological inhibition of epac1 for the treatment of

The present invention relates to the treatment of idiopathic pulmonary fibrosis. Today, there is no cure for IPF. The inventors showed that EPAC1 […]

Fucoidan-functionalized polysaccharide particles with t-pa for

There is a dire need for innovative nanomedicine-based solutions for safe and efficient thrombolysis with a non-toxic, biocompatible, and […]

Anti-cathepsin d human antibody for triple negative breast cancer

Inventors have generated two human anti-cath-D scFv fragments cloned in the human IgG1 ??format (F1 and E2) that efficiently bind to human and mouse […]