Rock inhibitors to treat diabetic retinopathy

In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. […]

Pyk2-based gene therapy gene therapy attenuates cognitive deficits

In the present invention it is shown that the inactivation of the Pyk2 gene does not alter hippocampal development but prevents hippocampal-dependent […]

Pyk2-based gene therapy attenuates cognitive deficits associated to

In the present invention it is shows that the inactivation of the Pyk2 gene does not alter hippocampal development but prevents hippocampal-dependent […]

Apelin receptor agonist for the treatment of post-operative cognitive

The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the […]

Anti notch3 antibody for cadasil treatment

The present invention relates to an anti-Notch 3 antibody therapy useful for treatment of patients with cerebral autosomal dominant arteriopathy with […]

Lipid antisens oligonucleotide targeting fxyd2 as a therapeutic agent

The present invention relates to an inhibitor of FXYD2 gene expression for use in a method for treating neuropathic pain in a patient in need thereof. […]

Soluble apps?-based gene therapy in alzheimer’s disease

The present invention relates to a method of treating Alzheimer’s disease by administration to the subject of a therapeutically effective amount of […]

Neuroglobin gene therapy for use in the treatment or prevention of a

Mitochondrial dysfunction is responsible for hereditary optic neuropathies. We wished to determine whether preserving mitochondrial […]

Antibody protecting from bscb leakage induced cns damages

The present invention relates to an anti-NMDA antibody or fragment or derivative thereof which is effective in inhibiting the deleterious effects of […]

M-csf for preventing or treating myeloid cytopenia and related

The invention relates to a method for preventing or treating myeloid cytopenia and related complications such as infections in patients undergoing […]