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Murine cholangiocarcinoma cell line SB1-JP4

The cholangiocarcinoma cell line SB1-JP4 is syngeneic to C57Bl/6 mice.

It was derived from a tumor formed by SB1 cells in C57Bl/6 mice, then harvested, dissociated ex vivo, single-cell isolated by flow cytometry sorting, and expanded as a monoclonal cell line in vitro.
Interest / Relevance: The list of murine cholangiocarcinoma cell lines is limited, yet these models are crucial for fundamental and preclinical studies of biliary tract cancer. Here, we describe a new cell line, syngeneic to immunocompetent C57Bl/6 mice, derived from an in vivo immunoedited tumor originating from the previously reported SB1 cells.
Keywords: Cholangiocarcinoma, Biliary tract cancer, Murine cell line
Scientist's name: M Jonathan POL
Juliette Paillet
Guido Kroemer
Publications:
- SB1-JP4 cells: Paillet J et al. J Exp Med. 2021 Oct 4,218(10):e20200853. doi: 10.1084/jem.20200853.



- Original SB1 cells: Ilyas S et al. Oncotarget. 2017 Dec 22,9(5):5892-5905. doi: 10.18632/oncotarget.23638.

Reference:

RT00735

Business Developper
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Inserm Transfert
Research Tools
Organism: Mus musculus
Tissue: Biliary tract
Culture Medium: DMEM supplemented with 10% (vol/vol) FBS and 100 IU/ml of penicillin G and 100 mg/ml streptomycin.
Rare disease: Yes
Last update: 14/02/2025

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