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Rat mesothelial cell line f1-3

Transformed rat mesothelial cell line isolated from the peritoneal fluid of a female rat (Fischer F344) after 307 days of induction with crocidolite (blue asbestos) injected intraperitoneously.

Interest / Relevance: - Academic Research: identification of markers of neoplastic / transformed mesothelial cells, analyses of chromosomal damage induced by asbestos, studies of the mechanism of asbestos-induced oncogenesis, implication of fibrosis and inflammation.
- Industry research: antibody production, screening of new anticancer agents, identification of factors that increase mesothelial proliferation and migration.
- Therapeutic: development of epigenetic drugs, design of cancer vaccines, regenerative medicine applications.

Cellular and Molecular Biology, Immunology.

Scientist's name: Daniel POULIQUEN

Reference:

RT00408

Type of research tool: Cell Lines

Therapy area(1): Oncology

Therapy area(2): Immunology

Uses(1): Academic Research

Uses(2): Proof of concept in vitro

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Organism: Rat

Tissue: Mesothelium (peritoneal cavity)

Morphology: sarcomatoid

Passage Number: 3, 5

Culture Medium: RPMI 1640 supplemented with 10% FCS and 2mM L-Glutamine

Growth Properties: under investigation

Karyotype: under investigation

Rare disease:

Last update: 08/02/2022

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