Rat mesothelial cell line M2-0

Transformed rat mesothelial cell line isolated from the peritoneal fluid of a male rat (Fischer F344) after 285 days of induction with crocidolite (blue asbestos) injected intraperitoneously in 2008.
Belongs to the epithelioid group and "Sbnl" (subnormal) subgroup (see publications 1 and 2 below for more details).
Several features (unpublished data, in line with specific growth properties) suggest this cell line started to evolve towards a neoplastic transformation, compared with F1-0e and F1-0f cell lines of the same Sbnl subgroup.
The complete proteomic analysis data of the biocollection of cell lines has been deposited on the PRIDE database website (http://www.ebi.ac.uk/pride), part of the ProteomeXchange Consortium, with the dataset identifier PXD060521.

Interest / Relevance: - Academic Research: identification of markers of neoplastic / transformed mesothelial cells, analyses of chromosomal damage induced by asbestos, studies of the mechanism of asbestos-induced oncogenesis, implication of fibrosis and inflammation.

- Industry research: antibody production, screening of new anticancer agents, identification of factors that increase mesothelial proliferation and migration.

- Therapeutic: development of epigenetic drugs, design of cancer vaccines, regenerative medicine applications.

Cellular and Molecular Biology, Immunology.

Keywords: mesothelial cells, epithelioid, tumor marker, tumor invasion process, malignant transformation, proliferation rate

Scientist's name: M Daniel L. POULIQUEN

Publications:

1- Oncotarget (2016) 7, 34664-34687, doi: 10.18632/oncotarget.8970

2- Cancers (2020) 12, 939, doi: 10.3390/cancers12040939

Reference:

RT00425