Biomarker for assessing or predicting the severity of asthma or allergic disease

The present invention relates to allergy field. Several independent groups have recently investigated the implication of PCSK9 on inflammation and sepsis but none of them have determine its impact on allergies and/or asthma which is a global health burden. Inventors have obtained preliminary data on wild-type (PCSK9+/+) or PCSK9-deficient mice (PCSK9-/-) and shown that, under basal condition and in the absence of a particular stimulus, PCSK9 deficiency significantly increases the percentage of regulatory T cells in the spleen, the mesenteric lymph nodes and Peyer’s patches. Moreover, inventors have shown the effect of allergic challenge on primary human bronchial epithelial cells on PCSK9 expression and secretion. Very interestingly, their first results obtained by Q-PCR showed that HDM and LPS increase PCSK9 mRNA levels. Accordingly, the present invention relates to inhibitors of PCSK9 for use in the treatment of asthma and/or allergic disease, such as food allergy.

Patent Application number: European Procedure (Patents) (EPA) - 05 Sept. 2018 - 18 306 169.6
Inventors:
CARIOU BertrandBOUCHAUD GrégoryMAGNAN AntoineLE MAY Cedric

Reference:

BIO18315-D1

Business Developper
contact
Inserm Transfert
Business Developer
Patent filling date: 05-09-2018
Rare disease: No
Second indication: No

You might also be interested in