Recombinant flagellin for preventing and treating respiratoryinfections / copd-ae

The present invention relates to the use of an optimized truncated flagellin (TLR5 agonist devoided of toxic effect) for preventing or treating respiratory tract infection. Both preventive and currative effects in the absence of any antibiotic have been demonstrated in a mouse model of infection with S. Pneumoniae. Action mechanism of this immunomodulator includes neutrophil infiltration into airways, upregulation of IL6, TNFa, CXCL1, CXCL2 and CCL20 genes and complete restoration of lung architecture within one week after treatment. Promising data obtained with this novel immunomodulator in combination with antibiotics in various mouse models (infection and superinfection/lung inflammation) open new doors in the field of prevention and treatment of nosocomial infections.

Keywords: Infectious diseases, bacterial infection, viral infection, superinfection, COPD acute exhacerbation, lung, flagellin, TLR, TLR-5, immunomodulator, antibiotics, nosocomial infections, prevention, treatment, Antibiotic combination, Innate immune system modulation, respiratory system, Streptococcus pneumoniae, vaccine, Leishmaniasis, adjuvant
Patent Application number: WO/2011/161491
Inventors:
Jean-Claude SIRARDJose A. CHABALGOITY
Publications:
Infect. Immunol 2010 Oct;78(10):4226-33

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