BIO14009-T1

New method for producing Outer Membrane Vesicles by hlyF-expressing E coli strains as vaccine component

The present invention relates to a method for producing outer membrane vesicles (OMVs) by expression or overexpression of the hemolysin F gene (hlyF) in gram-negative bacterium for use as vaccination vector.


Keywords : Vaccine, OMV, HlyF, hemolysin F gene, gram negative bacteria, ex-vivo production method
Patent Application number : EP14305508.5
Patent Application date : 2014-04-07
Multidisciplinary field : -
Technology/Engineering : -
Technological Platform : -
Rare disease : -
Second indication : -
Inventors : Eric OSWALD
Patricia MARTIN
Kazunori MURASE
Publications :
  • J Infect Dis. 2016 Mar 1;213(5):856-65. doi: 10.1093/infdis/jiv506. Epub 2015 Oct 22.

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