Methods for prognosing and treating metabolic diseases

The present invention relates to methods for prognosing and treating metabolic diseases. The inventors demonstrated the association of obesity with the increase of intestinal IDO activity, which shifts tryptophan (Trp) metabolism from indole derivative but also IL-22 production towards kynurenine (Kyn) production. The inventors showed that the rewiring of Trp metabolism is possible towards a microbiota-dependent production of IL-22. In particular, the present invention relates to a method of treating metabolic diseases in a subject in need thereof comprising administering to the subject a therapeutically effective amount of probiotics

Keywords : Diabetes, Hypertension, Insulin resistance, Dyslipidemia, Hyperlipidemia.
Patent Application number : EP18305219.0
Patent Application date : 2018-03-01
Multidisciplinary field : Microbiota
Technology/Engineering : -
Technological Platform : -
Rare disease : -
Second indication : -
Inventors : -
Publications :
  • Nat Med. 2018 Aug;24(8):1113-1120. doi: 10.1038/s41591-018-0060-4. Epub 2018 Jun 25.

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