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BIO19115-T1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF CARDIAC REMODELING

The present invention relates to the treatment of cardiac remodelling. In this study, the inventors demonstrated, using male Wistar rats submitted either to sham surgery or ligation of left anterior descending coronary artery to cause MI, that oral administration of the vitamin B3 nicotinamide riboside (NR), a precursor for NAD coenzyme that is used in energy metabolism prevents the onset of adverse cardiac remodeling after myocardial infarction and the development of systolic dysfunction. Thus, the present invention relates to the nicotinamide riboside for use in the treatment of cardiac remodeling in a subject in need thereof.


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