METHODS AND PHARMACEUTICAL COMPOSITIONS FOR PROVIDING CARDIOPROTECTION IN SUBJECTS WHO EXPERIENCED A MYOCARDIAL INFARCTION
Myocardial infarction occurs when the blood supply to part of the heart is interrupted causing some heart cells to die. The immediate goal is to restore blood flow to the patient as quickly as possible. However, a significant delay in restoring blood flow leads to a second condition known as ischemia-reperfusion injury that can develop gradually after an ischemic event and may cause irreversible damage to tissues. Successful cardioprotection is limited by a relatively small number of therapeutic targets. The present invention fulfils this need. The inventors indeed showed that a Selenoprotein T (SelT) derived peptide, SelT43-52 (PSELT), is effective against ischemia/reperfusion (I/R) injury.