The present invention relates to methods and compositions for the preservation of organs.
In particular, the present invention relates to an activator of PERK-ATF4 pathway, an inhibitor of the ATF6 pathway and an inhibitor of the RNase activity of IRE1α for use in the maintain of organ viability during cold ischemia.
The inventors showed that therapeutic intervention during cold ischemia could significantly alter outcome, suggesting active mechanisms taking place. More particularly, the inventors demonstrated that Unfolded Protein Response could be a critical pathway underlying the relationship between cold ischemia time and graft outcome, highlighting the potential for UPR-based therapeutics to improve transplantation efficiency.
Another aspect of the present invention relates to a device for preserving an organ, said device comprising an organ container filled with a preservation solution, characterized in that said device further comprises one or more mean for injecting one or more compound into the organ container.