Inhibitors of the pp1/gadd34 complex for the treatment of a condition requiring an immunosuppressive activity

The present invention relates to the general field of the treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the of treatment an immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.

Keywords: Inflammation, Infection, Auto-immunity, Graft versus Host Diseases, Rheumatoid Arthritis
Patent Application number: EP09 306 124 .0
Inventors:
Philippe PIERREEvelina GATTIGiovanna CLAVARINO
Publications:
Clavarino G. et al. Autoimmunity 2016 Feb DOI: 10.3109/08916934.2016.1138220 Clavarino G. et al. PNAS 2012 Feb 21 DOI: 10.1073/pnas.1104491109 Clavarino G. et al. PLoS Pathog 2012 May DOI: 10.1371/journal.ppat.1002708

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