Hmln (hgr) reporter cell line

HMLN were generated by transfection of cervical cancer HeLa cells with the MMTV- -Luciferase-SV40-Neomycin plasmid. The plasmid MMTV-Luc-SVNeo contains a luciferase gene driven by the mouse mammary tumor virus promoter and a neomycin phosphotransferase gene under the control of SV40 promoter.

Interest / Relevance: These cells enable to measure the hGR activity (full and partial agonism, antagonism) of pharmaceuticals (breast cancer, menopause treatment), environmental compounds (alkylphenols, bisphenol A, phthalates or pesticides, cosmetics).
These cells enable to measure the hGR activity of environmental (water, sediments), human (blood, urine adipose tissue) or food (water, vegetables, meat) samples.
Keywords: hGR, luciferase, pharmaceutical and environmental glucocorticoids
Scientist's name: Patrick BALAGUER
Patrick Balaguer

You might also be interested in


Inserm Transfert

Research tool licensing team