Anti-vwf d'd3 single-domain antibodies and polypeptides comprising thereof

The invention relates to isolated single-domain antibodies (sdAb) directed against von Willebrand Factor (VWF) D’D3 domain and chimeric polypeptides comprising thereof such as blood clotting factors and their uses in therapy such as in the prevention and treatment of hemostatic disorders. The invention also relates to a method of extending or increasing halflife of a therapeutic polypeptide comprising a step of adding to the polypeptide sequence of said therapeutic polypeptide at least one sdAb directed against VWF D’D3 domain.

Inventors:
Olivier CHRISTOPHEPeter LENTINGCécile DENISGabriel AYME

You might also be interested in