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BIO18132-T1

USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because of their multifactorial origin. SHP2 is a ubiquitous tyrosine phosphatase that regulates major signalling pathways (e.g. MAPK, PI3K) in response to many […]

BIO14414-T1

Apelin for the treatment of type 2 diabetes

Use of Apelin in humans has a positive effect on insulin sensitivity with a good tolerance and a good safety. Thus, a first object of the invention relates to an APJ receptor agonist for use in the treatment or the […]

BIO16235-T1

METHODS OF ENHANCING THE POTENCY OF INCRETIN-BASED DRUGS IN SUBJECTS IN NEED THEREOF

The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal models, the inventors identified that a specific gut microbiota signature impairs GLP-1-activated gut-brain axis which could be transferred to […]

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