BIO19344-T1
NEUTRALIZING GRANZYME B FOR PROVIDING CARDIOPROTECTION IN A SUBJECT WHO EXPERIENCED A MYOCARDIAL INFARCTION
The present invention relates to a method for providing cardioprotection in a subject who experienced a myocardial infarction comprising administering the subject with a therapeutically effective amount of a Granzyme B inhibitor. Here, the inventors show that following acute MI […]
BIO15275-T1
Antibody for the treatment of Myocardial Infarction
The present invention relates to a method for treating MI or AMI in a subject in need thereof comprising a step of administering to said subject a therapeutically effective amount of an agent capable of depleting CD8 T cells. More […]
BIO08404-T1
A B cell depleting agent for the treatment of Atherosclerosis or post Myocardial Infarction
New anti-atherogenic strategies based on B cell modulation, and suggest that patients currently treated with CD20 antibodies for other immune-mediated diseases might also benefit from a reduction of cardiovascular risk through limitation of atherosclerotic lesion development or inflammation. CD20-antibody-mediated depletion […]
BIO10733-T1
Microparticles for drug delivery
The present invention relates to covalently cross linked polysaccharide based – microparticles for the sustain and local release of potent growth factors and therapeutic proteins.
BIO15226-T1
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR CARDIAC REGENERATION
The adult mammalian heart regeneration is largely prevented by the limited proliferative capacity of the resident cardiomyocytes (CMs). Here, the inventors identify Ephrin-B1 as a new critical regulator of adult CM proliferation. CM-specific transgenic repression of Ephrin-B1 promotes adult CM […]
BIO13036-D1
BAFF expression for Monitoring Myocardial Infarction
Acute myocardial infarction is a severe ischemic disease responsible for heart failure and sudden death. Here, we show that after acute myocardial infarction in mice, mature B lymphocytes selectively produce Ccl7 and induce Ly6C(hi) monocyte mobilization and recruitment to the […]
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