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BIO19344-T1

NEUTRALIZING GRANZYME B FOR PROVIDING CARDIOPROTECTION IN A SUBJECT WHO EXPERIENCED A MYOCARDIAL INFARCTION

The present invention relates to a method for providing cardioprotection in a subject who experienced a myocardial infarction comprising administering the subject with a therapeutically effective amount of a Granzyme B inhibitor. Here, the inventors show that following acute MI […]

BIO15275-T1

Antibody for the treatment of Myocardial Infarction

The present invention relates to a method for treating MI or AMI in a subject in need thereof comprising a step of administering to said subject a therapeutically effective amount of an agent capable of depleting CD8 T cells. More […]

BIO08404-T1

A B cell depleting agent for the treatment of Atherosclerosis or post Myocardial Infarction

New anti-atherogenic strategies based on B cell modulation, and suggest that patients currently treated with CD20 antibodies for other immune-mediated diseases might also benefit from a reduction of cardiovascular risk through limitation of atherosclerotic lesion development or inflammation. CD20-antibody-mediated depletion […]

BIO10733-T1

Microparticles for drug delivery

The present invention relates to covalently cross linked polysaccharide based – microparticles for the sustain and local release of potent growth factors and therapeutic proteins.

BIO15226-T1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR CARDIAC REGENERATION

The adult mammalian heart regeneration is largely prevented by the limited proliferative capacity of the resident cardiomyocytes (CMs). Here, the inventors identify Ephrin-B1 as a new critical regulator of adult CM proliferation. CM-specific transgenic repression of Ephrin-B1 promotes adult CM […]

BIO13036-D1

BAFF expression for Monitoring Myocardial Infarction

Acute myocardial infarction is a severe ischemic disease responsible for heart failure and sudden death. Here, we show that after acute myocardial infarction in mice, mature B lymphocytes selectively produce Ccl7 and induce Ly6C(hi) monocyte mobilization and recruitment to the […]

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