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BIO1635101-T1

Gfi1 AS A NEW TARGET FOR THE TREATMENT OF HYPERGLYCEMIA AND DIABETES

Gfi1 is expressed in the pancreas, starting from the first stages of pancreatic embryonic development. Conditional knock out Gfi1 (exclusively in the pancreas) mice were found to be viable, fertile and to display a life expectancy comparable to that of […]

BIO19344-T1

NEUTRALIZING GRANZYME B FOR PROVIDING CARDIOPROTECTION IN A SUBJECT WHO EXPERIENCED A MYOCARDIAL INFARCTION

The present invention relates to a method for providing cardioprotection in a subject who experienced a myocardial infarction comprising administering the subject with a therapeutically effective amount of a Granzyme B inhibitor. Here, the inventors show that following acute MI […]

BIO18162-T1

USE OF PI3KC2¿ INHIBITORS FOR THE PRESERVATION OF VASCULAR ENDOTHELIAL CELL BARRIER INTEGRITY

Ischemic conditions are a leading cause of death for both men and women. Ischemia, a condition characterized by reduced blood flow and oxygen to an organ. Re-establishment of blood flow, or reperfusion, and re-oxygenation of the affected area following an […]

BIO13400-T1

Novel target candidate for the prevention and treatment of respiratory infections / COPD-AE

The present invention relates to methods and pharmaceutical compositions for the prevention and treatment of respiratory bacterial infections and more particularly of superinfection and acute exacerbation of chronic obstructive pulmonary disease with a therapeutically effective amount of an antagonist of […]

BIO19208-T1

USE OF CD9 AS A BIOMARKER AND AS A BIOTARGET IN GLOMERULONEPHRITIS

The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here the […]

BIO13410-T1

Monoacylglycerol lipase as target for the treatment of Liver Fibrosis

The present invention relates to methods and pharmaceutical compositions for the treatment of fibrosis. In particular, the present invention relates to a method of treating fibrosis in a subject in need thereof comprising administering the subject with a therapeutically effective […]

BIO19185-T1

USE OF INHIBITORS OF CUBILIN FOR THE TREATMENT OF CHRONIC KIDNEY DISEASES

Chronic Kidney Disease (CKD) is a major burden of public health affecting millions of people around the world. Even though many aspects of the complex mechanisms orchestrating progression of renal disease have been identified, so far there is no specific […]

BIO07572-T1

Treatment of bone mineral density related diseases

The present invention relates to methods of the treatment and diagnosis of bone mineral density related disorders. More particularly, the present invention relates to a method of diagnosing or predicting a bone mineral density related disease, or a risk of […]

BIO19230-T1

Use of NGAL Inhibitors for treating chronic wound

Chronic wounds and in particular diabetic ulcers are a serious complication of diabetes. Unresolved inflammation, associated with the dysregulation of both the phenotype and function of macrophages, is involved in the poor healing of diabetic wounds. Here, the inventor report […]

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