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BIO18132-T1

USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because of their multifactorial origin. SHP2 is a ubiquitous tyrosine phosphatase that regulates major signalling pathways (e.g. MAPK, PI3K) in response to many […]

BIO20193-T1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHRONIC KIDNEY DISEASE

The present invention relates to methods and pharmaceutical compositions for the treatment of chronic kidney disease. The inventors used the CMap resources to identify the sesquiterpene lactone parthenolide that was subsequently analyzed for its in vivo capacity to reduce the […]

BIO19115-T1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF CARDIAC REMODELING

The present invention relates to the treatment of cardiac remodelling. In this study, the inventors demonstrated, using male Wistar rats submitted either to sham surgery or ligation of left anterior descending coronary artery to cause MI, that oral administration of […]

MECA11013-T1

Transoesophageal device using high intensity focused ultrasounds for cardiac thermal ablation

The present invention relates to a probe comprising: a piezoelectric therapy transducer having an acoustic axis BB’, and an imaging transducer having an imaging plane, said therapy transducer and imaging transducer being mounted in a head itself connected to a […]

BIO15052-T1

Use of TLR7/8 agonists for the treatment ofinfections in cirrhotic patients

The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections in patients suffering from cirrhosis. In particular, the present invention relates to a method of treating bacterial infection in a patient suffering from cirrhosis comprising […]

BIO13024-T1

M-CSF for preventing or treating myeloid cytopenia and related complications following hematopoetic stem cell transplantation

The invention relates to a method for preventing or treating myeloid cytopenia and related complications such as infections in patients undergoing hematopoietic stem cell transplantation (HSCT). The approach is based on the priming of the hematopoietic stem cell graft with […]

BIO19208-T1

USE OF CD9 AS A BIOMARKER AND AS A BIOTARGET IN GLOMERULONEPHRITIS

The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here the […]

BIO15275-T1

Antibody for the treatment of Myocardial Infarction

The present invention relates to a method for treating MI or AMI in a subject in need thereof comprising a step of administering to said subject a therapeutically effective amount of an agent capable of depleting CD8 T cells. More […]

BIO19185-T1

USE OF INHIBITORS OF CUBILIN FOR THE TREATMENT OF CHRONIC KIDNEY DISEASES

Chronic Kidney Disease (CKD) is a major burden of public health affecting millions of people around the world. Even though many aspects of the complex mechanisms orchestrating progression of renal disease have been identified, so far there is no specific […]

BIO16119-T1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CARDIOMYOPATHIES

The present invention relates to methods and pharmaceutical compositions for the treatment of cardiomyopathies. The inventors showed that the nicotinamide riboside kinase Nmrk2 gene involved in NAD+ biosynthetic pathway is strongly induced in the heart of the mouse models of […]

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