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BIO10412-T1

Recombinant flagellin for preventing and treating respiratoryinfections / COPD-AE

The present invention relates to the use of an optimized truncated flagellin (TLR5 agonist devoided of toxic effect) for preventing or treating respiratory tract infection. Both preventive and currative effects in the absence of any antibiotic have been demonstrated in […]

BIO15066-T1

Ex-vivo active immunotherapy against infectious diseases and tumoral antigens for mimicking natural production by B cells of immunoglobulin

The present invention concerns lentiviral vectors enabling the expression of membrane-anchored and secreted antibodies by B cells. This invention results from the development of a new method for adoptive transfer of B-cells transduced with a lentiviral vector (LV) conditionally expressing […]

BIO14444-T1

ANTIBODIES SPECIFIC TO GLYCOPROTEIN (GP) OF EBOLAVIRUS AND USES FOR THE TREATMENT AND DIAGNOSIS OF EBOLA VIRUS INFECTION

The present invention relates to antibodies or fragments thereof that specifically bind to glycoprotein (GP) of Ebola virus, and to their use for treating and diagnosing Ebola virus disease.

BIO12320-T1

Fonctionalized microparticules as vaccination adjuvant and Ag vector for the development of therapeutic vaccines against cancer

The invention relates to microparticules fonctionalized with alphagalactosylceramide for sustained iNKT cell activation. Delivering of alphagalactosylceramide (a natural iNKT agonist presented by DC to iNKT cells) through functionalized microparticules allows to prevent the iNKT anergy observed with non vectorized alphagalactosylceramide. […]

BIO18315-T1

METHODS AND COMPOSITIONS FOR TREATING ASTHMA AND ALLERGIC DISEASES

The present invention relates to allergy field. Several independent groups have recently investigated the implication of PCSK9 on inflammation and sepsis but none of them have determine its impact on allergies and/or asthma which is a global health burden. Inventors […]

BIO15247-T1

Nanoblade technology: High efficiency delivery of CRISPRs components in primary cells by Virus Like Particles.

The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.

BIO13310-T1

Apelin analogs for the treatment of Heart Failure

The invention related to metabolically stable Apelin analogs and their use for the prevention or the treatment of diseases mediated by the apelin receptor in particular of cardiovascular disease (heart failure, hypertension, pulmonary hypertension, kidney failure) and inappropriate vasopressin secretions […]

BIO15295-T1

Mutated Factor X for the treatment of Haemophilia A and B

The present invention relates to mutated factor (FX) polypeptides and uses thereof for the treatment of haemophilia A and B.

BIO13275-T1

Mutated Factor X for the treatment of Haemophilia A and B

The present invention relates to mutated factor (FX) polypeptides and uses thereof for the treatment of haemophilia A and B.

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