A new Inserm Transfert Technology Offers experience coming soon in April !

BIO18132-T1

USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because of their multifactorial origin. SHP2 is a ubiquitous tyrosine phosphatase that regulates major signalling pathways (e.g. MAPK, PI3K) in response to many […]

BIO19230-T1

Use of NGAL Inhibitors for treating chronic wound

Chronic wounds and in particular diabetic ulcers are a serious complication of diabetes. Unresolved inflammation, associated with the dysregulation of both the phenotype and function of macrophages, is involved in the poor healing of diabetic wounds. Here, the inventor report […]

BIO11035-T1

GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis

GABA is an inducer of α-to-β-like cell conversion in vivo. This conversion induces α cell replacement mechanisms through the mobilization of duct-lining precursor cells that adopt an α cell identity prior to being converted into β-like cells, solely upon sustained […]

BIO17636-T1

USE OF TRIETHYLENETETRAMINE (TETA) FOR THE THERAPEUTIC INDUCTION OF AUTOPHAGY

Autophagy is a universal anti-aging mechanism the chronic induction of which can extend the health span and lifespan of mammals. Here the inventors show that triethylenetetramine (TETA), also called trientine, a drug that is approved for the treatment of Wilson […]

BIO15451-T1

Sphingosine kinase 1 a new tumor target for enhancing the potency of immune checkpoint inhibitors inhibitor for the treatment of cancer

The present invention relates to methods for enhancing the potency of the immune checkpoint inhibitors. In particular, the present invention relates to a method for enhancing the potency of an immune checkpoint inhibitor administered to a subject as part of […]

CHIM14143-T1

G quadruplex ligands to treat infectious diseases

The present inventions relate to – metallated porphyrin derivatives as ligands of G quadruplex and their use as anti-viral agents. Porphyrin derivatives candidates inhibits HIV replication with IC 50 around 100 nM in vitro. More specifically, this application is related […]

CHIM20164-T1

TRIARYLPYRIDINE COMPOUNDS AND USE THEREOF FOR TREATING CANCER

The invention relates to new bis-triazole 2,4,6-triarylpyridines compounds and their use in the field of oncology, in particular in the prevention and/or treatment of cancer disease. The inventors have observed that the new bis-triazole 2,4,6-triarylpyridines were able to induce cancer […]

BIO17360-T2

Methods and topical pharmaceutical compositions for the treatment of skin microvascular dysfunction

Microvascular dysfunction remains a major contributor to the development of skin complications. The inventors assessed the impact of the local inhibition of soluble epoxide hydrolase (sEH), which metabolizes vasodilator and anti-inflammatory epoxyeicosanoids, on the diabetic skin microvascular dysfunction. The inventors […]

BIO17393-T1

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) for the treatment of melanomas

The present invention relates to a method for treating a subject suffering from melanoma resistant by administering to said subject an inhibitor of NAMPT. Using a global metabolic profiling, inventors have showed that in addition to glycolysis, the BRAF inhbitor, […]

12 Last patents posted


The 10 Last viewed

You haven't seen any form yet.