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BIO1635101-T1

Gfi1 AS A NEW TARGET FOR THE TREATMENT OF HYPERGLYCEMIA AND DIABETES

Gfi1 is expressed in the pancreas, starting from the first stages of pancreatic embryonic development. Conditional knock out Gfi1 (exclusively in the pancreas) mice were found to be viable, fertile and to display a life expectancy comparable to that of […]

BIO19344-T1

NEUTRALIZING GRANZYME B FOR PROVIDING CARDIOPROTECTION IN A SUBJECT WHO EXPERIENCED A MYOCARDIAL INFARCTION

The present invention relates to a method for providing cardioprotection in a subject who experienced a myocardial infarction comprising administering the subject with a therapeutically effective amount of a Granzyme B inhibitor. Here, the inventors show that following acute MI […]

BIO18132-T1

USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because of their multifactorial origin. SHP2 is a ubiquitous tyrosine phosphatase that regulates major signalling pathways (e.g. MAPK, PI3K) in response to many […]

BIO20193-T1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHRONIC KIDNEY DISEASE

The present invention relates to methods and pharmaceutical compositions for the treatment of chronic kidney disease. The inventors used the CMap resources to identify the sesquiterpene lactone parthenolide that was subsequently analyzed for its in vivo capacity to reduce the […]

BIO19115-T1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF CARDIAC REMODELING

The present invention relates to the treatment of cardiac remodelling. In this study, the inventors demonstrated, using male Wistar rats submitted either to sham surgery or ligation of left anterior descending coronary artery to cause MI, that oral administration of […]

BIO18162-T1

USE OF PI3KC2¿ INHIBITORS FOR THE PRESERVATION OF VASCULAR ENDOTHELIAL CELL BARRIER INTEGRITY

Ischemic conditions are a leading cause of death for both men and women. Ischemia, a condition characterized by reduced blood flow and oxygen to an organ. Re-establishment of blood flow, or reperfusion, and re-oxygenation of the affected area following an […]

BIO10412-T1

Recombinant flagellin for preventing and treating respiratoryinfections / COPD-AE

The present invention relates to the use of an optimized truncated flagellin (TLR5 agonist devoided of toxic effect) for preventing or treating respiratory tract infection. Both preventive and currative effects in the absence of any antibiotic have been demonstrated in […]

BIO13024-T1

M-CSF for preventing or treating myeloid cytopenia and related complications following hematopoetic stem cell transplantation

The invention relates to a method for preventing or treating myeloid cytopenia and related complications such as infections in patients undergoing hematopoietic stem cell transplantation (HSCT). The approach is based on the priming of the hematopoietic stem cell graft with […]

BIO15066-T1

Ex-vivo active immunotherapy against infectious diseases and tumoral antigens for mimicking natural production by B cells of immunoglobulin

The present invention concerns lentiviral vectors enabling the expression of membrane-anchored and secreted antibodies by B cells. This invention results from the development of a new method for adoptive transfer of B-cells transduced with a lentiviral vector (LV) conditionally expressing […]

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