A new Inserm Transfert Technology Offers experience coming soon in April !

BIO1635101-T1

Gfi1 AS A NEW TARGET FOR THE TREATMENT OF HYPERGLYCEMIA AND DIABETES

Gfi1 is expressed in the pancreas, starting from the first stages of pancreatic embryonic development. Conditional knock out Gfi1 (exclusively in the pancreas) mice were found to be viable, fertile and to display a life expectancy comparable to that of […]

BIO19344-T1

NEUTRALIZING GRANZYME B FOR PROVIDING CARDIOPROTECTION IN A SUBJECT WHO EXPERIENCED A MYOCARDIAL INFARCTION

The present invention relates to a method for providing cardioprotection in a subject who experienced a myocardial infarction comprising administering the subject with a therapeutically effective amount of a Granzyme B inhibitor. Here, the inventors show that following acute MI […]

BIO18132-T1

USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because of their multifactorial origin. SHP2 is a ubiquitous tyrosine phosphatase that regulates major signalling pathways (e.g. MAPK, PI3K) in response to many […]

BIO20193-T1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHRONIC KIDNEY DISEASE

The present invention relates to methods and pharmaceutical compositions for the treatment of chronic kidney disease. The inventors used the CMap resources to identify the sesquiterpene lactone parthenolide that was subsequently analyzed for its in vivo capacity to reduce the […]

BIO19115-T1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF CARDIAC REMODELING

The present invention relates to the treatment of cardiac remodelling. In this study, the inventors demonstrated, using male Wistar rats submitted either to sham surgery or ligation of left anterior descending coronary artery to cause MI, that oral administration of […]

BIO18162-T1

USE OF PI3KC2¿ INHIBITORS FOR THE PRESERVATION OF VASCULAR ENDOTHELIAL CELL BARRIER INTEGRITY

Ischemic conditions are a leading cause of death for both men and women. Ischemia, a condition characterized by reduced blood flow and oxygen to an organ. Re-establishment of blood flow, or reperfusion, and re-oxygenation of the affected area following an […]

MECA11013-T1

Transoesophageal device using high intensity focused ultrasounds for cardiac thermal ablation

The present invention relates to a probe comprising: a piezoelectric therapy transducer having an acoustic axis BB’, and an imaging transducer having an imaging plane, said therapy transducer and imaging transducer being mounted in a head itself connected to a […]

BIO15052-T1

Use of TLR7/8 agonists for the treatment ofinfections in cirrhotic patients

The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections in patients suffering from cirrhosis. In particular, the present invention relates to a method of treating bacterial infection in a patient suffering from cirrhosis comprising […]

12 Last patents posted


The 10 Last viewed

You haven't seen any form yet.