Lymphotoxin alpha regulates the immunosuppressive functions of

The present invention relates to regulatory T cell and uses thereof. By their immunosuppressive and anti-inflammatory activities, regulatory T cells […]

Methods for the diagnosis and treatment of t cell-lymphomas ccr8

T-cell lymphomas are a heterogeneous group of malignancies involving T lymphocytes and generally characterized by a poor prognosis. Among them, […]

Anti-robo4 human monoclonal antibodies and usesthereof for the

There is an interest to develop anti-ROBO4 antibodies that can be suitable for the treatment of cancer. The inventors produced new human antibodies […]

Methods and pharmaceutical compositions for treating cancer

Tumour-specific molecular targets and alternative therapeutic strategies for triplenegative breast cancer (TNBC) are urgently needed. The protease […]

Anti-mÜllerian inhibiting substance antibodies and uses thereof

In ovarian carcinoma, Müllerian Inhibiting Substance (MIS) type II receptor (MISRII) and the MIS/MISRII signaling pathway are potential therapeutic […]

Bispecific antibody targeting transferrin receptor 1 and soluble

The invention relates to a bispecific antibody targeting TfR1 and a soluble antigen. The inventors demonstrate that the unique mode of interaction of […]

Chimeric proteins and methods of immunotherapy

Chimeric proteins for cancer immunotherapy can combine different activities bydisplaying both agonistic and antagonistic properties on a single […]

Novel target and mab candidates for the treatment of hcmv infection

The present invention relates to a method for treating an infection, particularly HCMV infection. To date, there are very few reports on the role of […]

Methods and composition to identify and treat subjects resisting to

The present invention relates to a method for treating a subject suffering from a cancer comprising a step of administering said subject with a […]

Use of an agent capable of inhibiting the activation of mait cells for

Obesity is associated with low-grade inflammation in adipose tissue (AT) and dysfunctional adipocytes producing inflammatory molecules. A recent study […]