A microrna switch regulates the rise in hypothalamic gnrh production

A method for diagnosing a reproduction-related disorder in an individual, comprising:a) measuring the level of a miR200 nucleic acid and/or miR155 […]

Modulator of wip1 levels to treat wolfram syndrome

The present invention relates to novel therapeutic ways for treating Wolfram Syndrome (WS) by targeting the neuronal calcium sensor 1 (NCS1). The […]

Vdac1 inhibition for the treatment of peripheral demyelination

Here the inventors show, using in vivo imaging and viral approaches, that calcium released by mitochondrial VDAC1 directly induces Schwann cell […]

Protease nexin-1 inhibitor for the treatment of haemorrhagic disease

The thrombogram of FVIII-KO mice displays a prolonged time to peak and a reduced peak thrombin. The addition of the neutralizing anti-protease nexin-1 […]

Apelin for the treatment of type 2 diabetes

Use of Apelin in humans has a positive effect on insulin sensitivity with a good tolerance and a good safety. Thus, a first object of the invention […]

Novel target candidate for the prevention and treatment of respiratory

The present invention relates to methods and pharmaceutical compositions for the prevention and treatment of respiratory bacterial infections and more […]

Ppar-gamma agonist as target for the treatment of rapidly progressive

This study demonstrates the pivotal role of the local PPAR-gamma agonist system in maintaining podocyte quiescence and orchestrating the global […]

Lipid antisens oligonucleotide targeting fxyd2 as a therapeutic agent

The present invention relates to an inhibitor of FXYD2 gene expression for use in a method for treating neuropathic pain in a patient in need thereof. […]

Apelin analogs for the treatment of dysfunction associated with aging

The inventors show that apelin plays a role in energy metabolism and particularly in energetic mechanisms in mitochondria. They show that apelin […]