New biomarkers and targets for prognosis in patients with renal cell

Renal Cell Carcinoma (RCC) encompasses a heterogeneous group of cancers derived from renal tubular epithelial cells and has a worldwide mortality. […]

Methods and pharmaceutical compositions for the treatment of acute

An easily administrable drug treatment to increase the recanalization rate associated with intravenously t-Pa would represent a major advance in the […]

Methods and compositions for treating cell senescence accumulation

The inventors have surprisingly demonstrated that GD3 positive senescent cells inhibit NK cell in vitro and in vivo while GD3 negative senescent cells […]

Neutralizing granzyme b for providing cardioprotection in a subject

The present invention relates to a method for providing cardioprotection in a subject who experienced a myocardial infarction comprising administering […]

A cxcr3b antagonist for the treatment of vitiligo

The present invention relates to a method for treating vitiligo in a subject in need thereof comprising a step of administering to said subject a […]

A pak1/2 inhibitor for the treatment of psoriasis and other nlrp3

The present invention relates to a PAK-1 and/or PAK-2 inhibitor for use in the treatment of NLRP3 inflammasome mediated IL-1beta dependent disorders […]

Methods for the diagnosis and treatment of gastrointestinal stromal

The present invention relates to the diagnosis of gastrointestinal stromal tumors (GISTs). The present invention also relates to methods and […]

A lyn kinase activator for the treatment of braf inhibitor-resistant

The present invention relates to method and composition for treating melanoma. The inventors have shown that a decrease in LYN expression, in melanoma […]

Sphingosine kinase 2 inhibitors in combination with immune checkpoint

Immune checkpoint blockade therapy is based on the inhibition of the tumor-mediated suppression of anticancer immune responses. However, the efficacy […]