Novel melanoma antigen peptide and uses thereof

The invention relates to peptides derived from the MELOE antigen for therapeutic vaccination against cancer. A phase I clinical trial for ex-vivo […]

Exon skipping therapy of erythropoietic protoporphyria

The present invention relates to methods and pharmaceutical compositions for the treatment of Erythropoietic Protoporphyria. In particular, the […]

Hydrophobically modified antisense oligonucleotides comprising a cetal

The present invention concerns an oligonucleotide modified by substitution at the 3’ or the 5’ end by at least triple alkyl chain or at least one […]

Novel target and mab candidates for the treatment of hcmv infection

The present invention relates to a method for treating an infection, particularly HCMV infection. To date, there are very few reports on the role of […]

Nanoparticle based glue, biocompatible sealant for surgery

The present invention relates to methods for adhering tissue surfaces and materials and biomedical uses thereof. In particular the present invention […]

Improved vector for driving the targeted integration of a transgene

The present invention relates to polypeptide for engineering integrase chimeric proteins and their use in gene therapy. A key challenge for gene […]

Ctip fusion to cas9 enhances transgene integration by

The present invention relates to nuclease protein fusions for enhancing genome editing by homology-directed transgene integration (HDI).The inventors […]

Pharmacologically active microcarriers for efficient integration of

This invention results from Pharmacologically Active Microcarriers (PAM) which are based on a biocompatible and biodegradable material. These […]

Methods of diagnosing acute circulatory failure

Circulatory failure generates hypoxia and leads to accumulation of reductive species in tissue and circulatory failure monitoring tools are needed but […]

Intestinal cathelicidin antimicrobial peptide shapes the gut

The present invention relates to the treatment of autoimmune diseases. The inventors determined that the cathelicidin related antimicrobial peptide […]