Bay-1895344 (elimusertib) from bayer in adult and pediatric liver

Pediatric liver cancers (PLC) are rare tumors. In particular, hepatoblastomas are usually treated with cisplatin-based neoadjuvant chemotherapy […]

Composition comprising furin-inhibited car macrophages and uses

CAR macrophages (CAR-M) can phagocyte tumor cells expressing a target antigen. It is herein shown that the proprotein convertase furin is […]

Methods and compositions for treating melanoma

Inventors have shown that targeting DDR1 and DDR2 collagen receptors by Imatinib resensitizes melanoma tumors to BRAFV600E to targeted therapy and […]

Methods for the treatment of anaplastic large cell lymphoma

Anaplastic large cell lymphoma (ALCL) is a rare and aggressive peripheral T-cell lymphomaaffects lymph nodes and extra-nodal sites with characteristic […]

Methods for treating notch1-driven cancers

T-cell acute lymphoblastic leukemias (T-ALL) are aggressive hematological malignancies associated with poor clinical outcome. TP53 alterations […]

Flt3 inhibitor for modulating macrophages polarization

The role of pro- and anti-inflammatory macrophages in disease depends on the specific disease and the balance between the two types of macrophages. […]

Methods for the treatment of adult t-cell leukemia/lymphoma

Adult T-cell leukemia/lymphoma (ATL) is an aggressive proliferation of mature activated CD4+ T cells associated with the human T-cell lymphotropic […]

Ex vivo gene therapy based vaccine with nucleic acid molecule encoding

The present invention relates to a method of treating a B-cell malignancy in a subject using a vaccine composition comprising a population of […]

Mitoception: novel method for the intracellular transfer of isolated

The present invention relates to a method for the intercellular transfer of an amount of mitochondria isolated from a population of donor cells into a […]

Safety and efficacy of mait cells for adoptive cell therapy prevention

The inventors explored in an allogeneic situation the regulatory potential of Mucosal-Associated Invariant T cells (MAIT cells), a population of […]