Targeting myeloperoxidase overcomes cytarabine resistance in human

Chemotherapy commonly alters cellular redox balance and increases the oxidative state. Recent studies have reported that chemoresistant cells have an […]

Enhancement of 5-fluorouracil cytotoxicity by pyridoxal 5’-phosphate

The invention relates to methods and pharmaceutical compositions for treating cancer in a subject in need thereof. The inventors thought that low […]

Use of fzd7 inhibitors for the treatment of retinal neovascularization

Retinal ischemia and abnormal blood vessels growth are major determinants in the pathogenesis of retinopathy of prematurity (ROP) and proliferative […]

Methods of treating heart failure

Worldwide, 1% to 2% of the general adult population have heart failure (HF), which is accompanied by reduced quality of life, high morbidity, […]

A checkpoint kinase 1 inhibitor sensitises cancer cells to

The present invention relates to the field of cancer treatment. In this study, the inventors sought to investigate whether this antiproliferative […]

Method and apparatus for acquiring a spatial map of auditory

This method for acquiring a spatial map of auditory perception of a subject comprises a plurality of successive test sequences, each test sequence […]

Pharmaceutical compositions for use in the treatment of brain injuries

The invention is in the field of neuroregenerative medicine. Controlling the fate of neural stem cells represents a key therapeutic strategy in […]

Pyk2-based gene therapy gene therapy attenuates cognitive deficits

In the present invention it is shown that the inactivation of the Pyk2 gene does not alter hippocampal development but prevents hippocampal-dependent […]

Pyk2-based gene therapy attenuates cognitive deficits associated to

In the present invention it is shows that the inactivation of the Pyk2 gene does not alter hippocampal development but prevents hippocampal-dependent […]

Ctip fusion to cas9 enhances transgene integration by

The present invention relates to nuclease protein fusions for enhancing genome editing by homology-directed transgene integration (HDI).The inventors […]