Method for early prediction of neurodegenerative decline

The present invention relates to a method for predicting risks of neurodegenerative decline of a patient, especially of mild cognitive impairment […]

Use of shp2 inhibitors for the treatment of insulin resistance

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because […]

Methods and pharmaceutical compositions for the treatment of chronic

The present invention relates to methods and pharmaceutical compositions for the treatment of chronic kidney disease. The inventors used the CMap […]

Hla-class ii artificial antigen presenting cells in cd4 + t cell-based

CD4 T cell help is essential to promote robust cytotoxic T cell responses and could be harnessed to improve outcomes of cancer immunotherapy. To […]

Combination of arsenic and interferon alpha for the treatment of

The present invention relates to methods and pharmaceutical compositions for the treatment of myeloproliferative disorders in patients presenting a […]

Retinoic acid and arsenic trioxide trigger degradation of mutated

The present invention relates to methods and pharmaceutical compositions for the treatment of acute myeloid leukemia. In particular, the present […]

Lymphotoxin alpha regulates the immunosuppressive functions of

The present invention relates to regulatory T cell and uses thereof. By their immunosuppressive and anti-inflammatory activities, regulatory T cells […]

Rankl to boost thymic regeneration

Cytoablative treatments lead to severe damages on thymic epithelial cells (TECs), which result in delayed de novo thymopoïesis and a prolonged period […]

Sphingosine kinase 1 a new tumor target for enhancing the potency of

The present invention relates to methods for enhancing the potency of the immune checkpoint inhibitors. In particular, the present invention relates […]

Chimeric receptor for use in whole-cell sensors for detecting analytes

The present invention relates to chimeric receptors that can be used in whole-cell sensors for detecting analytes of interest. The inventors showed […]